Lymphatic Filariasis: A Method to Identify Subclinical Lower Limb Change in PNG Adolescents
Identifieur interne : 004D70 ( Main/Exploration ); précédent : 004D69; suivant : 004D71Lymphatic Filariasis: A Method to Identify Subclinical Lower Limb Change in PNG Adolescents
Auteurs : Susan Gordon [Australie] ; Wayne Melrose [Australie] ; Jeffrey Warner [Australie] ; Petra Buttner [Australie] ; Leigh Ward [Australie]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Amplitude articulaire, Courbe ROC, Enfant, Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (diagnostic), Filariose lymphatique (physiopathologie), Humains, Jambe (anatomopathologie), Jambe (parasitologie), Jambe (physiopathologie), Jeune adulte, Lymphoedème (anatomopathologie), Lymphoedème (diagnostic), Lymphoedème (physiopathologie), Manométrie, Mâle, Papouasie - Nouvelle-Guinée, Statistique non paramétrique, Études de cohortes.
- MESH :
- anatomopathologie : Filariose lymphatique, Jambe, Lymphoedème.
- diagnostic : Filariose lymphatique, Lymphoedème.
- parasitologie : Jambe.
- physiopathologie : Filariose lymphatique, Jambe, Lymphoedème.
- Adolescent, Amplitude articulaire, Courbe ROC, Enfant, Femelle, Humains, Jeune adulte, Manométrie, Mâle, Papouasie - Nouvelle-Guinée, Statistique non paramétrique, Études de cohortes.
- Wicri :
- geographic : Papouasie-Nouvelle-Guinée.
English descriptors
- KwdEn :
- Adolescent, Child, Cohort Studies, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (pathology), Elephantiasis, Filarial (physiopathology), Female, Humans, Leg (parasitology), Leg (pathology), Leg (physiopathology), Lymphedema (diagnosis), Lymphedema (pathology), Lymphedema (physiopathology), Male, Manometry, Papua New Guinea, ROC Curve, Range of Motion, Articular, Statistics, Nonparametric, Young Adult.
- MESH :
- geographic : Papua New Guinea.
- diagnosis : Elephantiasis, Filarial, Lymphedema.
- parasitology : Leg.
- pathology : Elephantiasis, Filarial, Leg, Lymphedema.
- physiopathology : Elephantiasis, Filarial, Leg, Lymphedema.
- Adolescent, Child, Cohort Studies, Female, Humans, Male, Manometry, ROC Curve, Range of Motion, Articular, Statistics, Nonparametric, Young Adult.
Abstract
Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity.
Url:
DOI: 10.1371/journal.pntd.0001242
PubMed: 21811644
PubMed Central: 3139669
Affiliations:
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last="Gordon">Susan Gordon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville</wicri:regionArea><wicri:noRegion>Townsville</wicri:noRegion></affiliation></author><author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, 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(anatomopathologie)</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (physiopathologie)</term><term>Humains</term><term>Jambe (anatomopathologie)</term><term>Jambe (parasitologie)</term><term>Jambe (physiopathologie)</term><term>Jeune adulte</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (diagnostic)</term><term>Lymphoedème (physiopathologie)</term><term>Manométrie</term><term>Mâle</term><term>Papouasie - Nouvelle-Guinée</term><term>Statistique non paramétrique</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Jambe</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Jambe</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Leg</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Leg</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Jambe</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Leg</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Manometry</term><term>ROC Curve</term><term>Range of Motion, Articular</term><term>Statistics, Nonparametric</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Amplitude articulaire</term><term>Courbe ROC</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Manométrie</term><term>Mâle</term><term>Papouasie - Nouvelle-Guinée</term><term>Statistique non paramétrique</term><term>Études de cohortes</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Papouasie-Nouvelle-Guinée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melrose, Wd" uniqKey="Melrose W">WD Melrose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Hooper, Pj" uniqKey="Hooper P">PJ Hooper</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Biswas, G" uniqKey="Biswas G">G Biswas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Witt, C" uniqKey="Witt C">C Witt</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shenoy, Rk" uniqKey="Shenoy R">RK Shenoy</name></author><author><name sortKey="Suma, Tk" uniqKey="Suma T">TK Suma</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author><author><name sortKey="Padma, S" uniqKey="Padma S">S Padma</name></author><author><name sortKey="Rahmah, N" uniqKey="Rahmah N">N Rahmah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shenoy, Rk" uniqKey="Shenoy R">RK Shenoy</name></author><author><name sortKey="Suma, Tk" uniqKey="Suma T">TK Suma</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author><author><name sortKey="Dhananjaynan, G" uniqKey="Dhananjaynan G">G Dhananjaynan</name></author><author><name sortKey="Rahmah, N" uniqKey="Rahmah N">N Rahmah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shenoy, Rk" uniqKey="Shenoy R">RK Shenoy</name></author><author><name sortKey="Suma, Tk" uniqKey="Suma T">TK Suma</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author><author><name sortKey="Rahmah, N" uniqKey="Rahmah N">N Rahmah</name></author><author><name sortKey="Dhananjaynan, G" uniqKey="Dhananjaynan G">G Dhananjaynan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lammie, Pj" uniqKey="Lammie P">PJ Lammie</name></author><author><name sortKey="Cuenco, Kt" uniqKey="Cuenco K">KT Cuenco</name></author><author><name sortKey="Punkosdy, Ga" uniqKey="Punkosdy G">GA Punkosdy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfarr, Km" uniqKey="Pfarr K">KM Pfarr</name></author><author><name sortKey="Debrah, Ay" uniqKey="Debrah A">AY Debrah</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S Specht</name></author><author><name sortKey="Hoeraf, A" uniqKey="Hoeraf A">A Hoeraf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suma, Tk" uniqKey="Suma T">TK Suma</name></author><author><name sortKey="Shenoy, Rk" uniqKey="Shenoy R">RK Shenoy</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreyer, G" uniqKey="Dreyer G">G Dreyer</name></author><author><name sortKey="Addiss, D" uniqKey="Addiss D">D Addiss</name></author><author><name sortKey="Dreyer, P" uniqKey="Dreyer P">P Dreyer</name></author><author><name sortKey="Noroes, J" uniqKey="Noroes J">J Noroes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Addiss, D" uniqKey="Addiss D">D Addiss</name></author><author><name sortKey="Louis Charles, J" uniqKey="Louis Charles J">J Louis-Charles</name></author><author><name sortKey="Roberts, J" uniqKey="Roberts J">J Roberts</name></author><author><name sortKey="Leconte, F" uniqKey="Leconte F">F LeConte</name></author><author><name sortKey="Wendt, J" uniqKey="Wendt J">J Wendt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shenoy, Rk" uniqKey="Shenoy R">RK Shenoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koelmeyer, L" uniqKey="Koelmeyer L">L Koelmeyer</name></author><author><name sortKey="Shanley, K" uniqKey="Shanley K">K Shanley</name></author><author><name sortKey="Reul Hirche, H" uniqKey="Reul Hirche H">H Reul-Hirche</name></author><author><name sortKey="Piller, N" uniqKey="Piller N">N Piller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moseley, A" uniqKey="Moseley A">A Moseley</name></author><author><name sortKey="Piller, N" uniqKey="Piller N">N 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Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, S" uniqKey="Babu S">S Babu</name></author><author><name sortKey="Bhat, Sq" uniqKey="Bhat S">SQ Bhat</name></author><author><name sortKey="Pavan Kumar, N" uniqKey="Pavan Kumar N">N Pavan Kumar</name></author><author><name sortKey="Lipira, Ab" uniqKey="Lipira A">AB Lipira</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Landmann, F" uniqKey="Landmann F">F Landmann</name></author><author><name sortKey="Foster, Jm" uniqKey="Foster J">JM Foster</name></author><author><name sortKey="Slatko, B" uniqKey="Slatko B">B Slatko</name></author><author><name sortKey="Sullivan, W" uniqKey="Sullivan W">W Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noroes, J" uniqKey="Noroes J">J Noroes</name></author><author><name sortKey="Dreyer, G" uniqKey="Dreyer G">G Dreyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreyer, G" uniqKey="Dreyer G">G Dreyer</name></author><author><name sortKey="Noroes, J" uniqKey="Noroes J">J Noroes</name></author><author><name sortKey="Addiss, D" uniqKey="Addiss D">D Addiss</name></author><author><name sortKey="Santos, A" uniqKey="Santos A">A Santos</name></author><author><name sortKey="Medeiros, Z" uniqKey="Medeiros Z">Z Medeiros</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Gordon, Susan" sort="Gordon, Susan" uniqKey="Gordon S" first="Susan" last="Gordon">Susan Gordon</name></noRegion><name sortKey="Buttner, Petra" sort="Buttner, Petra" uniqKey="Buttner P" first="Petra" last="Buttner">Petra Buttner</name><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name><name sortKey="Ward, Leigh" sort="Ward, Leigh" uniqKey="Ward L" first="Leigh" last="Ward">Leigh Ward</name><name sortKey="Warner, Jeffrey" sort="Warner, Jeffrey" uniqKey="Warner J" first="Jeffrey" last="Warner">Jeffrey Warner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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